Hplc - Semisynthesis

HPLC

High Pressure Liquid Chromatography) and LPLC (low pressure) : preparative high performance liquid chromatography is similar to analytical HPLC but features increased injected mass with possibility to “stack” injections automatically. There’s technically no product limitation, but usually expensive.

Semisynthesis

Hemisynthesis or Semisynthesis or partial chemical synthesis is a type of chemical synthesis that uses compounds isolated from natural sources (e.g. plant material) as starting materials. These natural biomolecules are usually large and complex molecules. This is opposed to a total synthesis where large molecules are synthesized from a stepwise combination of small and cheap (petrochemical) building blocks. 

It is also possible that the semisynthetic derivative outperforms the original biomolecule itself with respect to potency, stability or safety. Drugs derived from natural sources are usually produced by harvesting the natural source or through semisynthetic methods.